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Antihyperlipidemic and Antioxidant Effects of Phaseolus Vulgaris Linn in Wistar Rats

Antihyperlipidemic and Antioxidant Effects of Phaseolus Vulgaris Linn in Wistar Rats

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Reference ID: PS-2441-TM

DEDICATION

This research work titled "Antihyperlipidemic and Antioxidant Effects of Phaseolus Vulgaris Linn in Wistar Rats" is dedicated to God for his enabling grace and to all computer enthusiasts who help to make life a pleasant experience.

ACKNOWLEDGEMENT

I owe my indebtedness to my Supervisor (Name of your Supervisor), the Head of Department (Name of your HOD), the Lecturers in the department of Pharmaceutical Technology / Science, Book Authors and Profound Scholars of existing/related research material for your moral support that facilitated the successful completion of my (Tertiary Institution level). I am grateful to God Almighty and my parent for their financial support in my career. I really appreciate you all for everything, Thank you very much.

ABSTRACT

In this study, the antihyperlipidemic and antioxidants activities of the extract and fractions ofPhaseolus vulgaris L. were evaluated. The crude extract (PVE) of dried pulverized plant materialwas obtained by maceration in methylene chloride/methanol (1:1) while the solvent fractionswere obtained by successive solvent-solvent partition in separating funnel between the crudeextract suspended in aqueous medium and solvents of increasing polarity to obtain the n-hexanefraction (PVHF), ethylacetate fraction (PVEF), and butanol fraction (PVBF) in thatorder.

Antihyperlipidemic effects of the extracts and fractions were investigated using acute, subacuteand chronic models. In all threemodels, treatment with (PVE) caused significantreduction(PPVEF (400 mg/kg)produced- the most significant reduction in total cholesterol level in the acute study withpercentage decrease of 22.10% compared to the control treatment. Triglycerides level wassimilarly reduced by 21.59% and 15.91% at PVHF (200 mg/kg) and PVEF (200 mg/kg) with theacute study.The sub-acute protocol showed significant decrease at PVBF 200 mg/kg percentagedecrease of 17.28%. VLDL-C level for the fraction study showed significant decrease (PLDL-C level for fraction extract study showed dosedependent significance decrease (PThe highest percentage reduction of nitric oxide was 75.86%seen with PVHF at 200 mg/kg. The in vitro study showed significant increased (P0.05) increase or decrease in the serumMDA of both the treated and untreated group, while in catalase activity estimation showedsignificant (P


Antihyperlipidemic and Antioxidant Effects of Phaseolus Vulgaris Linn in Wistar Rats

CHAPTER ONE

1.1 Introduction

… As a prelude to other parts of this study, this chapter will discuss the background upon which this study was initiated, the statement of problems that led to this study, the Aim and Objectives of the study. Others are Significance of the study, Scope of work, Research hypothesis and questions, Limitation of the study and Definition of technical terms.

CHAPTER TWO

2.0 Literature Review

2.1 Introduction

This chapter focuses on the review of related literature. A literature review includes the current knowledge as well as theoretical and methodological contributions to a particular topic. It documents the state of the art with respect to the topic you are writing. It surveys the literature in the topic selected. In this research work the literature review includes the …

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