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Hepatotoxicity of the Ethanolic Extracts of Enantia Chlorantha Root on Wistar Albino Rats
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Hepatotoxicity of the Ethanolic Extracts of Enantia Chlorantha Root on Wistar Albino Rats

The root of Enantia chlorontha was assayed for its hepatotoxicity effect. Extacts from the root were made using 95% ethanol. The root extracts were administered orally to 15 wistar albino rats and varying doses. 5 rats were kept as control group. The effect of the extracts was determined by assaying for the levels of serum-liver enzymes acting as biochemical makers. Liver enzymes assayed included Aspartate aminotransferase (AST), Alanin aminiotransferase (ALT) and alkaline phophatase (ALP). Comparison of the enzyme levels of the control group with these of the group administered with the rot extract revealed a significant elevation of liver enzyme levels.

Material Excerpt on Hepatotoxicity of the Ethanolic Extracts of Enantia Chlorantha Root on Wistar Albino Rats

TABLE OF CONTENTS

PRELIMINARY PAGES

  • Title page
  • Approval page
  • Dedication
  • Acknowledgement
  • Table of Contents
  • Abstract

CHAPTER ONE1.0 Introduction

  • 1.1 Background of the Study
  • 1.2 Aims and Objectives
  • 1.3 Statement of Problem
  • 1.4 Limitation of Study
  • 1.5 Significance of the Study

CHAPTER TWO

  • 2.0 Literature Review
  • 2.1 General Description of Enantia Chlorontha
  • 2.2 Ecological Distribution of Enantia Chlorantha
  • 2.3 Management and Propagation Practices
  • 2.4 Functional Uses
  • 2.5 Toxicity
  • 2.6 Hepatotoxicity
  • 2.7 Liver
  • 2.7.1 Liver Enzyme
  • 2.7.2 Some Pattern of Liver Injury
  • 2.7.3 Treatment/Prognosis of Liver Damage
  • 2.8 The Albino Rats
  • 2.9 Phytochemical Compounds

CHAPTER THREE

  • 3.0 Materials and Methods
  • 3.1 Collection, Identification and Processing of Plant Material
  • 3.1.1 Extraction of Plant Material
  • 3.1.2 Determination of the Weight of Dried Extract
  • 3.2 Phytochemcial Analysis
  • 3.3 Experimental Animal
  • 3.4 Determination of Dosage of the Plant Extract For Animal Feeding
  • 3.5 Grouping of Animal and Administration of Plant Extract
  • 3.6 Feeding Method
  • 3.7 Procedures For Blood Sample Collection
  • 3.7.1 Alanine Aminotransferase Test (Alt) Method For Alt Test
  • 3.7.2 Aspartate Animotransferase: (Ast) Method For Ast Test
  • 3.7.3 Alkaline Phousphatase: (Alp) Method For Alp Test

CHAPTER FOUR

  • 4.0 Results
  • 4.1 Result of the Photochemical Analysis of the Ethanolic Extract of Enantia Chlorontha
  • 4.2 Hepatotoxicity Assay

CHAPTER FIVE

  • 5.1 Discussion
  • 5.2 Conclusion
  • 5.3 Recommendation

REFERENCES

CHAPTER ONE

1.1 Introduction

In this section, Hepatotoxicity of the Ethanolic Extracts of Enantia Chlorantha Root on Wistar Albino Rats is discussed, with relevant and recent citations. As a prelude to other parts of this study, this chapter will discuss the background upon which this study was initiated, the statement of problems that led to this study, the aim and objectives of the study. Others are significance of the study, scope of work, research hypothesis and questions, limitation of the study and definition of terms.

CHAPTER TWO

LITERATURE REVIEW

2.1 Introduction

This chapter focuses on the review of related literature. A literature review presents current knowledge, as well as theoretical and methodological contributions, related to Hepatotoxicity of the Ethanolic Extracts of Enantia Chlorantha Root on Wistar Albino Rats. It documents the state of the art on the subject under study and provides a comprehensive survey of existing literature. In this research work the literature review includes the conceputal review, theoretical framework, the review of related literature …

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