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Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment

Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment

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DEDICATION

This research material, titled “Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment” is dedicated to God for His boundless grace and guidance. It is also a tribute to all computer enthusiasts whose contributions made my research journey smoother and enriched my documentation process, making the experience truly fulfilling.



ACKNOWLEDGEMENT

I am profoundly grateful to everyone who contributed to the successful completion of this project. I am especially grateful to my Supervisor (Name), the Head of Department (Name), and the Lecturers in the Department of Science and Engineering for their invaluable guidance and support. I also acknowledge the contributions of authors and scholars whose works on Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment provided essential insights. Special thanks go to my study area (and any funding organizations, if applicable) for their financial assistance. I am equally thankful to stakeholders, including mentors, teachers, and colleagues, for their encouragement and support. Finally, I deeply appreciate my family and friends for their patience and unwavering support throughout this journey. Your contributions have been instrumental in making this research a reality.



ABSTRACT

The number one killer disease in the world is Cardiovascular Disease1. The most serious element of Cardiovascular Disease is Coronary Artery Disease. Currently, the main treatment for Coronary Artery Disease is stent placement surgery. However, its long time safety and efficiency are the major setbacks, as it is associated with late restenosis and late thrombosis. These are set caused by the durable polymeric film used as the drug carrier.

To improve on the current treatment (stent placement surgery), a biodegradable drug delivery system was synthesized. Paclitaxel was successfully entrapped into the polylactide-co-glycolide acids microspheres via single solvent microencapsulation evaporation method. Optical Microscopy was used to study the shape and morphology of the microspheres. The particle sizes were found to range of the microspheres is 15. 18 — 40.11µm, with a mean size of 29.415 µm, a p-value 0.986 and a z-value-0.02.

The results suggest that the encapsulated drug loaded microspheres can be used as biodegradable drug eluting structures for localized vascular-targeted therapy for the treatment of coronary artery disease. This is a presented as potential alternative to stent placement surgery. The potential extensions to localized cancer treatment are also elucidated.


Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment

CHAPTER ONE

1.0 Introduction and Background of the Study

1.1 Statement of the problem (Heart Disease)

Cardiovascular disease (CVD) is caused by disorders of the heart and blood vessels, which includes coronary heart disease (heart attacks), cerebrovascular disease (stroke), raised blood pressure (hypertension), peripheral artery disease, rheumatic heart disease, congenital heart disease and heart failure [1,2]. The first two are the major killer diseases in the whole world.

In 2002, it was estimated that 29% of deaths worldwide (16.7 million deaths) were due to CVD and that 43% of global morbidity and mortality, measured in disability-adjusted life years (DALYs), and was caused by CVD. Furthermore, 78% of global mortality and 86% of mortality and morbidity from CVD occurs in developing countries.

…

CHAPTER TWO

2.0 Literature Review

2.1 Introduction

This chapter focuses on the review of related literature. A literature review includes the current knowledge as well as theoretical and methodological contributions to a particular topic. It documents the state of the art with respect to the topic you are writing. It surveys the literature in the topic selected. In this research work the literature review includes the conceputal review, theoretical framework, the review of related literature …

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