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Paclitaxel Loaded PolylactideCoGlycolide Acids for Coronary Artery Disease and Cancer Treatment

Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment

Project / Seminar Material
Reference ID: PS-1524-TM

DEDICATION

This research material titled “Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment” is dedicated to God for his enabling grace, and to all computer enthusiasts who contributed to make life a pleasant experience during my research documentation.

ACKNOWLEDGEMENT

I extend my sincere gratitude to all those who contributed to the completion of this project. Special thanks to my Supervisor (Name of your Supervisor), the Head of Department (Name of your HOD), the Lecturers in the department of Science and Engineering, Book Authors and Profound Scholars of existing or related project material on “Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment” for their invaluable guidance, support, and expertise throughout the journey.

I am also grateful to your study area (mention any funding organizations, if applicable) for their financial assistance. This research would not have been possible without the encouragement and assistance of some stakeholders (mention any mentors, teachers, or colleagues). Additionally, I would like to acknowledge the understanding and patience of my family and friends during this endeavor. Your unwavering support has been a constant source of motivation. Thank you all for being part of this meaningful endeavor.

ABSTRACT

The number one killer disease in the world is Cardiovascular Disease1. The most serious element of Cardiovascular Disease is Coronary Artery Disease. Currently, the main treatment for Coronary Artery Disease is stent placement surgery. However, its long time safety and efficiency are the major setbacks, as it is associated with late restenosis and late thrombosis. These are set caused by the durable polymeric film used as the drug carrier.

To improve on the current treatment (stent placement surgery), a biodegradable drug delivery system was synthesized. Paclitaxel was successfully entrapped into the polylactide-co-glycolide acids microspheres via single solvent microencapsulation evaporation method. Optical Microscopy was used to study the shape and morphology of the microspheres. The particle sizes were found to range of the microspheres is 15. 18 — 40.11µm, with a mean size of 29.415 µm, a p-value 0.986 and a z-value-0.02.

The results suggest that the encapsulated drug loaded microspheres can be used as biodegradable drug eluting structures for localized vascular-targeted therapy for the treatment of coronary artery disease. This is a presented as potential alternative to stent placement surgery. The potential extensions to localized cancer treatment are also elucidated.


Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment

CHAPTER ONE

1.0 Introduction and Background of the Study

1.1 Statement of the problem (Heart Disease)

Cardiovascular disease (CVD) is caused by disorders of the heart and blood vessels, which includes coronary heart disease (heart attacks), cerebrovascular disease (stroke), raised blood pressure (hypertension), peripheral artery disease, rheumatic heart disease, congenital heart disease and heart failure [1,2]. The first two are the major killer diseases in the whole world.

In 2002, it was estimated that 29% of deaths worldwide (16.7 million deaths) were due to CVD and that 43% of global morbidity and mortality, measured in disability-adjusted life years (DALYs), and was caused by CVD. Furthermore, 78% of global mortality and 86% of mortality and morbidity from CVD occurs in developing countries.

CHAPTER TWO

2.0 Literature Review

2.1 Introduction

This chapter focuses on the review of related literature. A literature review includes the current knowledge as well as theoretical and methodological contributions to a particular topic. It documents the state of the art with respect to the topic you are writing. It surveys the literature in the topic selected. In this research work the literature review includes the …

Summary Headlines for Paclitaxel Loaded Polylactide-Co-Glycolide Acids for Coronary Artery Disease and Cancer Treatment



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