This page presents an excerpt of the available research material, including the Preliminary Pages, Table of Contents, Abstract, Chapters One to Five, and References. It provides a comprehensive overview of the study, enhancing readability and accessibility for students, and researchers seeking complete material on “The Effect of Cisampelous Owarensis Benzene Fraction on Glucose Absorption across the Intestinal Epithelium of Wister Rats on Aloxan Induced Diabetes”.
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Diabetes is a global public health crisis that threatens the economies of all nations, particularly developing countries. It is generally characterized by hyperglycaemia and hyperlipidaemia culminating in severe morbidities. This study aimed to assess the effects of Cissampelos owanrensis on glucose absorption in alloxan-induced diabetic male Wistar rats.
Twenty (20) adult Wistar rats were divided into four (4) groups of five rats each (n=5). Groups 1 and 2 served as the control groups and group 3 and 4 were induced with diabetes by an intraperitoneal injection of alloxan (40mg/kg). The normoglycaemic groups (1 and 2) and the alloxan-induced diabetic groups (3 and 4) were treated with 300mg/kg of Cissampelos owanrensis. The fasting glucose level of the animals was monitored at 1 hour, 3 hours and 4 hours. At the end of the experiment the rats were sacrificed by cervical dislocation, blood samples were centrifuged to obtain the serum for biochemical analysis.
The duodenum, jejunum and ileum were excised for biochemical study. Data obtained were analyzed using SPSS statistical tool and expressed as mean±SEM. Results show that fasting blood glucose levels of diabetic rats was reduced significantly on administration of 300mg/kg of the plant extract(502.33±5.57 after 1 hour, 427.33±7.67 after 3 hours, 298.33±10.91 after 4 hours). In conclusion, benzene fractions of Cissampelos owanrensis demonstrated significant reduction in glucose absorption across the intestinal epithelium.
1.1 Introduction
… As a prelude to other parts of this study, this chapter will discuss the background upon which this study was initiated, the statement of problems that led to this study, the Aim and Objectives of the study. Others are Significance of the study, Scope of work, Research hypothesis and questions, Limitation of the study and Definition of technical terms.…
