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Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate

Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate

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DEDICATION

This research material, titled “Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate” is dedicated to God for His boundless grace and guidance. It is also a tribute to all computer enthusiasts whose contributions made my research journey smoother and enriched my documentation process, making the experience truly fulfilling.



ACKNOWLEDGEMENT

I am profoundly grateful to everyone who contributed to the successful completion of this project. I am especially grateful to my Supervisor (Name), the Head of Department (Name), and the Lecturers in the Department of Chemistry for their invaluable guidance and support. I also acknowledge the contributions of authors and scholars whose works on Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate provided essential insights. Special thanks go to my study area (and any funding organizations, if applicable) for their financial assistance. I am equally thankful to stakeholders, including mentors, teachers, and colleagues, for their encouragement and support. Finally, I deeply appreciate my family and friends for their patience and unwavering support throughout this journey. Your contributions have been instrumental in making this research a reality.



TABLE OF CONTENTS

PRELIMINARY PAGES

CHAPTER ONE

INTRODUCTION

    CHAPTER TWO

    LITERATURE REVIEW

    • 2.1 Introduction
    • ⋮

    CHAPTER THREE

    MATERIALS AND METHODS

    • 3.1 Introduction
    • ⋮

    CHAPTER FOUR

    RESULTS AND DISCUSSION

    • 4.1 Introduction
    • 4.2 Results
    • ⋮
    • 4.3 Discussion of Findings

    CHAPTER FIVE

    SUMMARY, CONCLUSION AND RECOMMENDATION

    • 5.1 Introduction
    • 5.2 Summary
    • 5.3 Conclusion
    • 5.4 Recommendation

    REFERENCES


    ABSTRACT

    This work is to check for the renal protective effect of ginger on rats which were given nitrate-treated drinking water. 21 wistar albino rats were divided into four groups (A, B, C, D). Group A which contains 5 rats served as the control group. They were fed with normal feed and normal drinking water. Group B (made up of 6 rats) were fed with feed formulated with 2.4g of ginger and water treated with 400mg/l of NaNo3. Group C (containing 5 rats) were fed with normal feed and water treated with 400mg/l of NaNO3. Group D (containing 5 rats) were fed with feed formulated with 2.4g of ginger and 2% ascorbic acid, and water treated with 400mg/l of NaNo3. Kidney function tests-urea and creatinine, were carried out on the blood samples of all the 4 groups.

    The results of the analysis were as follows: urea level; for group A (control) = 4.42mmol/l; group B (nitrate + ginger) = 6.03mmol/l, group C (nitrate only) = 5.36mmol/l, group D (nitrate + ascorbic acid = 6.06mmol/l. creatinine level; group A (control) = 96µmol/l, group B = 106.33µmol/l, group C = 105.4µmol/l, group D = 92.2µmol/l. Using creatinine which is strong biomarker for kidney dysfunction, there was no significant difference between the normal control and the treatment groups (p>0.05). So 400mg/l level of nitrate administered to the rats did not have significant adverse effect on them and the 2% ginger helped in the proper functioning of the kidney as shown in their increased final weights.


    Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate

    CHAPTER ONE

    1.1 Introduction

    … As a prelude to other parts of this study, this chapter will discuss the background upon which this study was initiated, the statement of problems that led to this study, the Aim and Objectives of the study. Others are Significance of the study, Scope of work, Research hypothesis and questions, Limitation of the study and Definition of technical terms.…

    CHAPTER TWO

    2.0 Literature Review

    2.1 Introduction

    This chapter focuses on the review of related literature. A literature review includes the current knowledge as well as theoretical and methodological contributions to a particular topic. It documents the state of the art with respect to the topic you are writing. It surveys the literature in the topic selected. In this research work the literature review includes the conceputal review, theoretical framework, the review of related literature …

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