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Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate

Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate

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Reference ID: PS-862-TM

DEDICATION

This research work titled "Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate" is dedicated to God for his enabling grace and to all computer enthusiasts who help to make life a pleasant experience.

ACKNOWLEDGEMENT

I owe my indebtedness to my Supervisor (Name of your Supervisor), the Head of Department (Name of your HOD), the Lecturers in the department of Chemistry, Book Authors and Profound Scholars of existing/related research material for your moral support that facilitated the successful completion of my (Tertiary Institution level). I am grateful to God Almighty and my parent for their financial support in my career. I really appreciate you all for everything, Thank you very much.

TABLE OF CONTENTS

PRELIMINARY PAGES


CHAPTER ONE

INTRODUCTION


    CHAPTER TWO

    LITERATURE REVIEW

    • 2.1 Introduction

    CHAPTER THREE

    MATERIALS AND METHODS

    • 3.1 Introduction

    CHAPTER FOUR

    RESULTS AND DISCUSSION

    • 4.1 Introduction
    • 4.2 Results
    • 4.3 Discussion of Findings

    CHAPTER FIVE

    SUMMARY, CONCLUSION AND RECOMMENDATION

    • 5.1 Introduction
    • 5.2 Summary
    • 5.3 Conclusion
    • 5.4 Recommendation

    REFERENCES

    ABSTRACT

    This work is to check for the renal protective effect of ginger on rats which were given nitrate-treated drinking water. 21 wistar albino rats were divided into four groups (A, B, C, D). Group A which contains 5 rats served as the control group. They were fed with normal feed and normal drinking water. Group B (made up of 6 rats) were fed with feed formulated with 2.4g of ginger and water treated with 400mg/l of NaNo3. Group C (containing 5 rats) were fed with normal feed and water treated with 400mg/l of NaNO3. Group D (containing 5 rats) were fed with feed formulated with 2.4g of ginger and 2% ascorbic acid, and water treated with 400mg/l of NaNo3. Kidney function tests-urea and creatinine, were carried out on the blood samples of all the 4 groups.

    The results of the analysis were as follows: urea level; for group A (control) = 4.42mmol/l; group B (nitrate + ginger) = 6.03mmol/l, group C (nitrate only) = 5.36mmol/l, group D (nitrate + ascorbic acid = 6.06mmol/l. creatinine level; group A (control) = 96µmol/l, group B = 106.33µmol/l, group C = 105.4µmol/l, group D = 92.2µmol/l. Using creatinine which is strong biomarker for kidney dysfunction, there was no significant difference between the normal control and the treatment groups (p>0.05). So 400mg/l level of nitrate administered to the rats did not have significant adverse effect on them and the 2% ginger helped in the proper functioning of the kidney as shown in their increased final weights.


    Renal Protective Effect of Ginger on Wistar Albino Rat Fed with Drinking Water Containing Nitrate

    CHAPTER ONE

    1.1 Introduction

    … As a prelude to other parts of this study, this chapter will discuss the background upon which this study was initiated, the statement of problems that led to this study, the Aim and Objectives of the study. Others are Significance of the study, Scope of work, Research hypothesis and questions, Limitation of the study and Definition of technical terms.

    CHAPTER TWO

    2.0 Literature Review

    2.1 Introduction

    This chapter focuses on the review of related literature. A literature review includes the current knowledge as well as theoretical and methodological contributions to a particular topic. It documents the state of the art with respect to the topic you are writing. It surveys the literature in the topic selected. In this research work the literature review includes the …

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