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Wound Healing and Anti-Inflammatory Activities of Ceiba Pentendra (L.) Gaertn in Wistar Rats

Wound Healing and Anti-Inflammatory Activities of Ceiba Pentendra (L.) Gaertn in Wistar Rats

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DEDICATION

This research material, titled “Wound Healing and Anti-Inflammatory Activities of Ceiba Pentendra (L.) Gaertn in Wistar Rats” is dedicated to God for His boundless grace and guidance. It is also a tribute to all computer enthusiasts whose contributions made my research journey smoother and enriched my documentation process, making the experience truly fulfilling.



ACKNOWLEDGEMENT

I am profoundly grateful to everyone who contributed to the successful completion of this project. I am especially grateful to my Supervisor (Name), the Head of Department (Name), and the Lecturers in the Department of Pharmaceutical Technology / Science for their invaluable guidance and support. I also acknowledge the contributions of authors and scholars whose works on Wound Healing and Anti-Inflammatory Activities of Ceiba Pentendra (L.) Gaertn in Wistar Rats provided essential insights. Special thanks go to my study area (and any funding organizations, if applicable) for their financial assistance. I am equally thankful to stakeholders, including mentors, teachers, and colleagues, for their encouragement and support. Finally, I deeply appreciate my family and friends for their patience and unwavering support throughout this journey. Your contributions have been instrumental in making this research a reality.



ABSTRACT

Wound healing is a natural process that enables tissue repair after an injury while inflammation is a pathophysiological response of living tissue to injuries. To shorten the duration and minimize associated complications of wounds, wounds are treated with medications. Currently there is a growing interest in the use of traditional wound dressing agents such as plant extracts. One plant used traditionally in wound treatment is Ceiba pentendra. In view of its use in wound care, we investigated the wound healing activities of whole extract and fractions of Ceiba pentendra extract using excision and incision wound models while the Anti-inflammatory activities of the whole extract and fractions was investigated using paw edema and cotton pellets model. Excision wounds were created, and treated with ointments prepared from Ceiba pentendra, incision wounds were also created in rats with both treated topically with preparations of extract and fractions with the wound healing activities of ointment assessed by rates of wound contraction and epithelialization.

Anti-inflammatory activities were assessed by treating with extract and fractions orally. Ceiba pentendra ointments shows significantly (p Anti-inflammatory effects using cotton-pellets showed that granuloma tissues formed in the extract treated groups were significantly (p There was a dose dependent inhibition for the hexane fractions; hence inhibition was seen at 200 mg/kg at the fourth hour with percentage inhibition of 31.25%, while no effect was seen with HXCP-100 mg/kg. The ethylacetate fraction also showed significant inhibition at all dose level starting at the third hour for EACP-100 mg/kg with percentage inhibition of 21.05% and the fourth hour for EACP-200 mg/kg with percentage of 22.22%. Maximum percentage inhibition was seen of 46.15% was seen at HXCP- 200 mg/kg, EACP-100 mg/kg and BNCP-200 mg/kg. The results obtained showed that Ceiba pentendra has good wound healing and antibacterial activities. These findings validate the use of this plant in traditional medicine for treatment of wounds.


Wound Healing and Anti-Inflammatory Activities of Ceiba Pentendra (L.) Gaertn in Wistar Rats

CHAPTER ONE

1.1 Introduction

… As a prelude to other parts of this study, this chapter will discuss the background upon which this study was initiated, the statement of problems that led to this study, the Aim and Objectives of the study. Others are Significance of the study, Scope of work, Research hypothesis and questions, Limitation of the study and Definition of technical terms.…

CHAPTER TWO

2.0 Literature Review

2.1 Introduction

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