Wound Healing and Anti-Inflammatory Activities of Ceiba Pentendra (L.) Gaertn in Wistar Rats

Wound healing is a natural process that enables tissue repair after an injury while inflammation is a pathophysiological response of living tissue to injuries. To shorten the duration and minimize associated complications of wounds, wounds are treated with medications. Currently there is a growing interest in the use of traditional wound dressing agents such as plant extracts. One plant used traditionally in wound treatment is Ceiba pentendra. In view of its use in wound care, we investigated the wound healing activities of whole extract and fractions of Ceiba pentendra extract using excision and incision wound models while the Anti-inflammatory activities of the whole extract and fractions was investigated using paw edema and cotton pellets model. Excision wounds were created, and treated with ointments prepared from Ceiba pentendra, incision wounds were also created in rats with both treated topically with preparations of extract and fractions with the wound healing activities of ointment assessed by rates of wound contraction and epithelialization.

Anti-inflammatory activities were assessed by treating with extract and fractions orally. Ceiba pentendra ointments shows significantly (p Anti-inflammatory effects using cotton-pellets showed that granuloma tissues formed in the extract treated groups were significantly (p There was a dose dependent inhibition for the hexane fractions; hence inhibition was seen at 200 mg/kg at the fourth hour with percentage inhibition of 31.25%, while no effect was seen with HXCP-100 mg/kg. The ethylacetate fraction also showed significant inhibition at all dose level starting at the third hour for EACP-100 mg/kg with percentage inhibition of 21.05% and the fourth hour for EACP-200 mg/kg with percentage of 22.22%. Maximum percentage inhibition was seen of 46.15% was seen at HXCP- 200 mg/kg, EACP-100 mg/kg and BNCP-200 mg/kg. The results obtained showed that Ceiba pentendra has good wound healing and antibacterial activities. These findings validate the use of this plant in traditional medicine for treatment of wounds.