Project Topics Seminar Topics School of Nursing Exam PDF Sign Up
Search Topic
PARKLYN
ERVICES
 · RC: 2994849
Sparklyn Evaluation of the Antihyperglyceamic Effects of Polar Partition Fractions of Hoslundia Opposita Leaf
WhatsApp Channel

Evaluation of the Antihyperglyceamic Effects of Polar Partition Fractions of Hoslundia Opposita Leaf

This page presents an excerpt of the research material, providing a comprehensive overview of the study. It includes the Preliminary Pages, Table of Contents, Abstract, Chapters One to Five, and References, making it accessible and informative for students, researchers, and other readers interested in the topic of this study. Acknowledgement is also included, expressing gratitude to the individuals, institutions, and resources that contributed to the successful completion of the research, with materials and information sourced from the online platform sparklyn.com.ng, which provided valuable academic support.

TABLE OF CONTENTS

PRELIMINARY PAGES

  • Title page
  • Approval page
  • Dedication
  • Acknowledgement
  • Table of Contents
  • Abstract

CHAPTER ONE

INTRODUCTION

    CHAPTER TWO

    LITERATURE REVIEW

    • 2.1 Introduction
    • ⋮

    CHAPTER THREE

    MATERIALS AND METHODS

    • 3.1 Introduction
    • ⋮

    CHAPTER FOUR

    RESULTS AND DISCUSSION

    • 4.1 Introduction
    • 4.2 Results
    • ⋮
    • 4.3 Discussion of Findings

    CHAPTER FIVE

    SUMMARY, CONCLUSION AND RECOMMENDATION

    • 5.1 Introduction
    • 5.2 Summary
    • 5.3 Conclusion
    • 5.4 Recommendation

    REFERENCES

    ABSTRACT

    Hoslundia opposita leaf is used folklorically in the management of diabetes and a preliminary anti-hyperglycaemic activity has been reported for its methanol extract. Therefore, in this study, the antihyperglyceamic activities of the partition fractions of Hoslundia opposita leaf was investigated using glucose loaded wistar rats with a view to determine the most active fraction. A 1% Tween 80 in normal saline and glibenclamide (5 mg/kg) were used as the negative and positive controls, respectively.

    The methanolic extract of the plant was successively partitioned into n-hexane, chloroform, ethylacetate, and evaporated to dryness in vacuo to obtain their corresponding n-hexane, chloroform, ethylacetate and aqueous fractions, which were similarly tested for their anti-hyperglyceamic activities. Activities of the fractions were statistically compared with themselves, and those of the positive and negative controls using ANOVA, followed by Student Newman Kuels’ test to determine the most active fraction. The methanolic extract of H. opposita (200, 400 mg/kg) gave a similar profile of activity with glibenclamide probably indicating both extra-pancreatic and insulin release effects.

    The similar results given by 200 and 400 mg/kg confirmed that the constituents are probably acting in synergism as the extract was significantly more active than the partition fractions or the most active constituents are in the non-polar fractions. The activities of the fractions were significantly less than that of the standard drug used, glibenclamide (5 mg/kg). The comparable (p > 0.05) 20 % anti-hyperglycaemic activity given by both ethylacetate and aqueous fractions at 400 and 200 mg/kg, respectively may indicate that both demonstrated moderate anti-hyperglycaemic activity, depending on the dose.

    Also, since their greatest activity was at 4 h, both fractions may elicit their antihyperglycaemic activity by stimulating insulin release. Only aqueous fraction gave a possible mild extrapancreatic effect. The antihyperglycaemic constituents in these fractions are likely to be moderately polar to polar in nature. Therefore, the totality of the results established the anti-hyperglycaemic activity of H. opposita and its usage in ethnomedicinal management of diabetes.

    CHAPTER ONE

    1.0 Introduction

    Medicinal plant is any plant, which in one or more of its organs, contains substances that can be used for therapeutic purposes or which are precursors for the synthesis of useful drugs (Sofowora, 2008). The practice of using plants in treating diseases is called herbal medicine and it dates back to very earliest periods of known human history. There is evidence of the use of herbs in the treatment of diseases and for revitalising body systems in almost all ancient civilisations − The Indian, Egyptian, Chinese and even the Greek and Roman civilisations (Bakhru, 1992).

    The universal role of plants in the treatment of diseases is exemplified by their employment in all the major systems of medicine, irrespective of the underlying philosophical premise (Evans, 2008). Examples of different diseases that plants have been used to treat include heart disorders, digestive disorders, constipation, diarrhoea, gonorrhoea, skin diseases, stomach ache, craw craw, asthma, toothache, hypertension (Bakhru, 1992; Evans, 2008). Some drugs of importance for the treatment of various diseases, which have been obtained from plants include atropine, bromelain, caffeine, cocaine, codeine, digoxin, emetine, morphine, noscapine, pilocarpine and quinine (Ertug, 2000).

    …

    CHAPTER TWO

    LITERATURE REVIEW

    2.1 Introduction

    This chapter focuses on the review of related literature. A literature review presents current knowledge, as well as theoretical and methodological contributions, related to Evaluation of the Antihyperglyceamic Effects of Polar Partition Fractions of Hoslundia Opposita Leaf. It documents the state of the art on the subject under study and provides a comprehensive survey of existing literature. In this research work the literature review includes the conceputal review, theoretical framework, the review of related literature …

    How to Download the Complete PDF Material (Table of Contents, Abstract, Chapter 1-5, and References)

    Above is a preview excerpt of the full study on “Evaluation of the Antihyperglyceamic Effects of Polar Partition Fractions of Hoslundia Opposita Leaf”. The complete material, including all five chapters, is available for download upon request. Get in touch with us here!

    Download Material (Docx)